In the TNM system, the tumor spread (staging) assessed:
- T = tumor size, with T for small tumors of T1 to T3 or T4 enough for large tumors.
- N = lymph nodes: N1 is the involvement of lymph nodes in the vicinity of the tumor, N2 and N3 to attack more distant lymph nodes.
- M = metastases (secondary tumors): M1 states that have formed somewhere in the body metastases.
- G = histological classification (grading) to malignancy (malignancy) of the tumor: G1 (low virulence) to G4 (severe malignancy).

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